Why is my Windows Audio disabled?

I have no playback nor recording when I have Windows Audio selected:

18:29:39 Failed to open Speakers (Realtek High Definition Audio)!

18:29:39 Audio Playback is disabled.

18:29:39 Failed to open Microphone (Realtek High Definition Audio)!

18:29:39 Audio Recording is disabled.

When I got into Song Setup the inputs and outputs are correctly setup but have "disabled" above each chael.

When I've plugged in an audiobox that works okay but recently my Windows Audio just isn't working with Studio One 2 Artist?