Audiobox iTwo Windows 10 when I'm talking on skype have some problems

Windows 10 when I'm talking on skype my friends don't hear me from my mic, but when they hear me i don't hear them. In my system, when I use mic, my speakers iTwo inactive, and when I my speakers iTwo my mic inactive. Please help me to solve this problem. Thanks

I'm using: Audiobox iTwo bundle, Windows 10 1703, mic M7 presonus, i7-4770k, 24gb ram